Synthesis, Characterization, and Application of BaTiO3 Nanoparticles for Anti-Cancer Activity
نویسندگان
چکیده
Abstract Barium titanate (BaTiO 3 ) nanoparticles (BTNPs) have been considered as emerging materials in biomedical sector through last decades due to the excellent physicochemical properties such dielectric and piezoelectric structures, biocompatibility, nonlinear optical characteristics. In this study, BTNPs were synthesized via co-precipitation method using barium carbonate titanium dioxide by stirring for 5 h. Then, it was annealed at 850 °C h with five different concentrations: 0.2, 0.4, 0.6, 0.8, 1 g/mL. The structural, morphological, analyses demonstrated characterization techniques X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive (EDX), thermogravimetric analysis (TGA), Raman, UV–visible spectroscopy. perovskite phase of BTNPs, an intense peak 31.6°, observed lowest concentration (0.2 g/mL), average crystalline size 1.42 nm based on XRD pattern. results justified SEM EDX. TGA adequate thermal stability material. EDX confirmed composition Ti, Ba, O elements. Raman peaks 305 cm −1 517 formation BaTiO . spectra presented that its’ absorbance edge shifted into visible range 404 nm. Application breast cancer cell line (MCF-7) significant dispersion effect 0.4 0.6 g/mL A strong toxicity rate has against MCF-7 line. Maximum % viability loss, $$\cong$$ ≅ 57% recorded 200 µg/mL minimum loss 19% 50 BTNPs. a higher BTPNs dosage more effective inhibition cells. Therefore, can be recommended promising nanomaterial anti-cancer drug discovery.
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ژورنال
عنوان ژورنال: Journal of Cluster Science
سال: 2022
ISSN: ['1040-7278', '1572-8862']
DOI: https://doi.org/10.1007/s10876-022-02346-y